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KMID : 0861120040080020171
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Korean Journal of Oriental Preventive Medicine
2004 Volume.8 No. 2 p.171 ~ p.184
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Effects of Gagamyounjo-Tang on the Experimentally Hypercoagulable State and Hyperlipidemia in Rats
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Kim Yong-Tae
Soh Kyung-Soon
Jeong Chan-Gil
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Abstract
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In order to study the effects of Gagamyounjo-Tang(Ê¥ÊõëÈðÏ÷·) on the experimentally hypercoagulable state and hyperlipidemia in rats, we have made the hypercoagulable state in rats by injection of Bothrops jararaca venom (0.1ml/200g : Control group), and have administered solid extract of Gagamyounjo-Tang(Ê¥ÊõëÈðÏ÷·)(132mg/200g : Sample group). After 1 hour we measured the platelet count, fibrinogen level, APTT, FDP and D-dimer. And we have made the hyperlipidemia in rats by injection of Triton WR-1339 for 3 days(30mg/200g/day : Control group), and have administered solid extract of Gagamyounjo-Tang(Ê¥ÊõëÈðÏ÷·)(132mg/200g : Sample group), then we measured the total cholesterol, triglyceride, phoshpolipid and HDL-cholesterol levels. The results are summarized as follows : 1. In the hypercoagulable state, Sample group significantly decreased in platelet count compared with Control group(p<0.01), and significantly prolonged in APTT compared with Control group(p<0.05). 2. In the hyperlipidemia, Sample group significantly decreased in the total cholesterol, triglyceride and phoshpolipid compared with Control group(p<0.01), and significantly increased in HDL-cholesterol level compared with Control group(p<0.01). According to the above experimental results, Gagamyounjo-Tang(Ê¥ÊõëÈðÏ÷·)is assumed to have curative effects against the hypercoagulable state in rats induced by Bothrops jararaca venom and the hyperlipidemia in rats induced by Triton WR-1339. And we can suppose that Gagamyounjo-Tang(Ê¥ÊõëÈðÏ÷·) has a curative effect against the cerebrovascular accident caused by blood stasis.
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KEYWORD
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Gagamyounjo-Tang, Bothrops Jararaca Venom, Hypercoagulable State, Platelet, Fibrinogen, APTT, FDP, D-dimer, Triton WR-1339, Hyperlipidemia, Total Cholesterol, Triglyceride, Phoshpolipid, HDL-cholesterol
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